Insight into oral amphiphilic cyclodextrin nanoparticles for colorectal cancer: comprehensive mathematical model of drug release kinetic studies and antitumoral efficacy in 3D spheroid colon tumors

• Sedat Ünal,
• Gamze Varan,
• Juan M. Benito,
• Yeşim Aktaş and
• Erem Bilensoy

Beilstein J. Org. Chem. 2023, 19, 139–157, doi:10.3762/bjoc.19.14

• formulation approaches for targeting the colon through oral administration. In our previous studies, oral chemotherapy for colon tumors was aimed and promising results were obtained with formulation development studies, mucin interaction, mucus penetration, cytotoxicity, and permeability in 2D cell culture

• , there is an intense focus on oral drug delivery, especially in the treatment of chronic diseases such as cancers. Even though there have been many developments in the field of chemotherapy in recent years, both in terms of diagnosis and treatment, oral chemotherapy has not yet been fully achieved due to

• encapsulation into nanoparticles, is an approach worth investigating. Conclusion Oral cancer therapy is still a milestone, attracting researchers' efforts, especially in cancers with high mortality such as CRC. Any progress in this area would be very promising. In this context, oral chemotherapy formulations in

Formulation development, stability and anticancer efficacy of core-shell cyclodextrin nanocapsules for oral chemotherapy with camptothecin

• Hale Ünal,
• Naile Öztürk and
• Erem Bilensoy

Beilstein J. Org. Chem. 2015, 11, 204–212, doi:10.3762/bjoc.11.22

• as CPT which may contribute to patient quality of life and drug efficacy in cancer therapy. Keywords: amphiphilic cyclodextrin; camptothecin; core-shell; nanocapsule; oral chemotherapy; Introduction Cancer is one of the major fatal diseases in the world and causes abnormal growth of cells spreading

• growth. Although in cancer therapy, the intravenous route is more common than the others, it is thought that with recent advances oral chemotherapy will be the breakthrough step in future chemotherapy [4]. From the patient’s viewpoint, the oral route allows for painless self-medication and thus it is

• occurs via the intravenous route [6][7]. However most anticancer drugs are not good candidates for oral delivery owing to their low absorption in the gastrointestinal tract (GI) and as a result exhibit low oral bioavailability [8][9]. In order to develop an effective oral chemotherapy, the